Inatomi T, Matsuda S, Ishiuchi T, Do Y, Nakayama M, Abe S, Kasho K, Wanrooij S, Nakada K, Ichiyanagi K, Sasaki H, Yasukawa T, Kang D.

TFB2M and POLRMT are essential for mammalian mitochondrial DNA replication

Biochim Biophys Acta Mol Cell Res. 2022 Jan;1869(1):119167.

[pubmed]

Fukuda H, Chujo T, Wei FY, Shi SL, Hirayama M, Kaitsuka T, Yamamoto T, Oshiumi H, Tomizawa K.

Cooperative methylation of human tRNA3Lys at positions A58 and U54 drives the early and late steps of HIV-1 replication

Nucleic Acids Res. 2021 Nov 18;49(20):11855-11867. 

[pubmed]

Ogawa A, Wei FY.

Protocol for preparation and measurement of intracellular and extracellular modified RNA using liquid chromatography-mass spectrometry

STAR Protoc. 2021 Sep 27;2(4):100848. 

[pubmed]

Shi SL, Fukuda H, Chujo T, Kouwaki T, Oshiumi H, Tomizawa K, Wei FY.

Export of RNA-derived modified nucleosides by equilibrative nucleoside transporters defines the magnitude of autophagy response and Zika virus replication

RNA Biol. 2021 Aug 12:1-18. 

[pubmed]

Miwa T, Wei FY, Tomizawa K.

Cdk5 regulatory subunit-associated protein 1 knockout mice show hearing loss phenotypically similar to age-related hearing loss

Mol Brain. 2021 May 17;14(1):82. 

[pubmed]

Nagayoshi Y, Chujo T, Hirata S, Nakatsuka H, Chen CW, Takakura M, Miyauchi K, Ikeuchi Y, Carlyle BC, Kitchen RR, Suzuki T, Katsuoka F, Yamamoto M, Goto Y, Tanaka M, Natsume K, Nairn AC, Suzuki T, Tomizawa K, Wei FY.

Loss of Ftsj1 perturbs codon-specific translation efficiency in the brain and is associated with X-linked intellectual disability

Sci Adv. 2021 Mar 26;7(13):eabf3072.

[pubmed]

Ogawa A, Nagiri C, Shihoya W, Inoue A, Kawakami K, Hiratsuka S, Aoki J, Ito Y, Suzuki T, Suzuki T, Inoue T, Nureki O, Tanihara H, Tomizawa K, Wei FY.

N ⁶-methyladenosine (m ⁶ A) is an endogenous A3 adenosine receptor ligand

Mol Cell. 2021 Feb 18;81(4):659-674.e7. 

[pubmed]

selected as a 'Research Highlight' in Nature Chemical Biology

2020年度

Tomizawa K, Wei FY.

Posttranscriptional modifications in mitochondrial tRNA and its implication in mitochondrial translation and disease

J Biochem. 2020 Nov 1;168(5):435-444.  Review

[pubmed]

Kanno A, Asahara SI, Furubayashi A, Masuda K, Yoshitomi R, Suzuki E, Takai T, Kimura-Koyanagi M, Matsuda T, Bartolome A, Hirota Y, Yokoi N, Inaba Y, Inoue H, Matsumoto M, Inoue K, Abe T, Wei FY, Tomizawa K, Ogawa W, Seino S, Kasuga M, Kido Y.

GCN2 regulates pancreatic β cell mass by sensing intracellular amino acid levels

JCI Insight. 2020 May 7;5(9):e128820. 

[pubmed]

Hirayama M, Wei FY, Chujo T, Oki S, Yakita M, Kobayashi D, Araki N, Takahashi N, Yoshida R, Nakayama H, Tomizawa K.

FTO Demethylates Cyclin D1 mRNA and Controls Cell-Cycle Progression

Cell Rep. 2020 Apr 7;31(1):107464.

[pubmed]

Miyazaki T, Sasaki SI, Toyoda A, Wei FY, Shirai M, Morishita Y, Ikegami T, Tomizawa K, Honda A.

Impaired bile acid metabolism with defectives of mitochondrial-tRNA taurine modification and bile acid taurine conjugation in the taurine depleted cats

Sci Rep. 2020 Mar 18;10(1):4915.

[pubmed]

2019年度以前

Naito T, Ercan B, Krshnan L, Triebl A, Koh DHZ, Wei FY, Tomizawa K, Torta FT, Wenk MR, Saheki Y.

Movement of accessible plasma membrane cholesterol by the GRAMD1 lipid transfer protein complex

Elife. 2019 Nov 14;8:e51401.

[pubmed]

Yamamoto T, Fujimura A, Wei FY, Shinojima N, Kuroda JI, Mukasa A, Tomizawa K.

2-Methylthio Conversion of N6-Isopentenyladenosine in Mitochondrial tRNAs by CDK5RAP1 Promotes the Maintenance of Glioma-Initiating Cells

iScience. 2019 Nov 22;21:42-56. 

[pubmed]

Shinoda S, Kitagawa S, Nakagawa S, Wei FY, Tomizawa K, Araki K, Araki M, Suzuki T, Suzuki T.

Mammalian NSUN2 introduces 5-methylcytidines into mitochondrial tRNAs

Nucleic Acids Res. 2019 Sep 19;47(16):8734-8745. 

[pubmed]

Takesue Y, Wei FY, Fukuda H, Tanoue Y, Yamamoto T, Chujo T, Shinojima N, Yano S, Morioka M, Mukasa A, Kuratsu J, Tomizawa K.

Regulation of growth hormone biosynthesis by Cdk5 regulatory subunit associated protein 1-like 1 (CDKAL1) in pituitary adenomas

Endocr J. 2019 Sep 28;66(9):807-816.

[pubmed]

Takenouchi T, Wei FY, Suzuki H, Uehara T, Takahashi T, Okazaki Y, Kosaki K, Tomizawa K.

Noninvasive diagnosis of TRIT1-related mitochondrial disorder by measuring i ⁶ A37 and ms ²i ⁶ A37 modifications in tRNAs from blood and urine samples

Am J Med Genet A. 2019 Aug;179(8):1609-1614. Review 

[pubmed]

Doki T, Yamashita S, Wei FY, Hara K, Yamamoto T, Zhang Z, Zhang X, Tawara N, Hino H, Uyama E, Kurashige T, Maruyama H, Tomizawa K, Ando Y.

Mitochondrial localization of PABPN1 in oculopharyngeal muscular dystrophy

Lab Invest. 2019 Nov;99(11):1728-1740.

[pubmed]

Mon EE, Wei FY, Ahmad RNR, Yamamoto T, Moroishi T, Tomizawa K.

Regulation of mitochondrial iron homeostasis by sideroflexin 2

J Physiol Sci. 2019 Mar;69(2):359-373.

[pubmed]

Fakruddin, M., Wei, F.-Y., Suzuki, T., Asano, K., Kaieda, T., Omori, A., Izumi, R., Fujimura, A., Kaitsuka, T., Miyata, K., Araki, K., Oike, Y., Scorrano, L., Suzuki, T., and Tomizawa, K.

Defective Mitochondrial tRNA Taurine Modification Activates Global Proteostress and Leads to Mitochondrial Disease.
Cell Rep., vol. 22, no. 2, 482 (2018) [pubmed]

Akaike, T., Ida, T., Wei, F.-Y., Nishida, M., Kumagai, Y., Alam, M. M., Ihara, H., Sawa, T., Matsunaga, T., Kasamatsu, S., Nishimura, A., Morita, M., Tomizawa, K., Nishimura, A., Watanabe, S., Inaba, K., Shima, H., Tanuma, N., Jung, M., Fujii, S., Watanabe, Y., Ohmuraya, M., Nagy, P., Feelisch, M., Fukuto, J. M., and Motohashi, H. 
Cysteinyl-tRNA synthetase governs cysteine polysulfidation and mitochondrial bioenergetics. 
Nat. Commun., vol. 8, no. 1, 1177 (2017) [pubmed]

Fakruddin, M., Wei, F.-Y., Emura, S., Matsuda, S., Yasukawa, T., Kang, D., and Tomizawa, K.
Cdk5rap1-mediated 2-methylthio-N6-isopentenyladenosine modification is absent from nuclear-derived RNA species. 
Nucleic Acids Res., vol. 45, no. 20, pp. 11954–11961 (2017) [pubmed]

Takahashi, N., Wei, F.-Y., Watanabe, S., Hirayama, M., Ohuchi, Y., Fujimura, A., Kaitsuka, T., Ishii, I., Sawa, T., Nakayama, H., Akaike, T., and Tomizawa, K. 
Reactive sulfur species regulate tRNA methylthiolation and contribute to insulin secretion.

Nucleic Acids Res., vol. 45, no. 1, pp. 435–445 (2017) [pubmed]

Wu, Y., Wei, F.-Y., Kawarada, L., Suzuki, T., Araki, K., Komohara, Y., Fujimura, A., Kaitsuka, T., Takeya, M., Oike, Y., Suzuki, T., and Tomizawa, K. 
Mtu1-Mediated Thiouridine Formation of Mitochondrial tRNAs Is Required for Mitochondrial Translation and Is Involved in Reversible Infantile Liver Injury. 
PLoS Genet., vol. 12, no. 9, e1006355 (2016) [pubmed]

Wei, F.-Y., Zhou, B., Suzuki, T., Miyata, K., Ujihara, Y., Horiguchi, H., Takahashi, N., Xie, P., Michiue, H., Fujimura, A., Kaitsuka, T., Matsui, H., Koga, Y., Mohri, S., Suzuki, T., Oike, Y., and Tomizawa, K. 
Cdk5rap1-mediated 2-methylthio modification of mitochondrial tRNAs governs protein translation and contributes to myopathy in mice and humans. 
Cell Metab., vol. 21, no. 3, pp. 428–442 (2015) [pubmed]

Zhou, B., Wei, F.-Y., Kanai, N., Fujimura, A., Kaitsuka, T., and Tomizawa, K. 
Identification of a splicing variant that regulates type 2 diabetes risk factor CDKAL1 level by a coding-independent mechanism in human. 
Hum. Mol. Genet., vol. 23, no. 17, pp. 4639–4650 (2014) [pubmed]

Xie, P., Wei, F.-Y., Hirata, S., Kaitsuka, T., Suzuki, T., Suzuki, T., and Tomizawa, K.
Quantitative PCR measurement of tRNA 2-Methylthio modification for assessing type 2 diabetes risk.
Clin. Chem., vol. 59, no. 11, pp. 1604–1612 (2013) [pubmed]

Ueda, Y.,  Wei, F.-Y., Hide, T.-I., Michiue, H., Takayama, K., Kaitsuka, T., Nakamura, H., Makino, K., Kuratsu, J.-I., Futaki, S., and Tomizawa, K. 
Induction of autophagic cell death of glioma-initiating cells by cell-penetrating d-isomer peptides consisting of Pas and the p53 C-terminus. 
Biomaterials, vol. 33, no. 35, pp. 9061–9069 (2012) [pubmed]

Wei, F.-Y., Suzuki, T., Watanabe, S., Kimura, S., Kaitsuka, T., Fujimura, A., Matsui, H., Atta, M., Michiue, H., Fontecave, M., Yamagata, K., Suzuki, T., and Tomizawa, K. 
Deficit of tRNALys modification by Cdkal1 causes the development of type 2 diabetes in mice.
J. Clin. Invest., vol. 121, no. 9, pp. 3598–3608 (2011) [pubmed]

Arragain, S., Handelman, S. K., Forouhar, F., Wei, F.-Y., Tomizawa, K., Hunt, J. F., Douki, T., Fontecave, M., Mulliez, E., and Atta, M. 
Identification of eukaryotic and prokaryotic methylthiotransferase for biosynthesis of 2-methylthio-N6-threonylcarbamoyladenosine in tRNA. 
J. Biol. Chem., vol. 285, no. 37, pp. 28425–28433 (2010) [pubmed]

Wei, F.-Y., Nagashima, K., Ohshima, T., Saheki, Y., Lu, Y.-F., Matsushita, M., Yamada, Y., Mikoshiba, K., Seino, Y., Matsui, H., and Tomizawa, K. 
Cdk5-dependent regulation of glucose-stimulated insulin secretion. 
Nat. Med., vol. 11, no. 10, pp. 1104–1108 (2005) [pubmed]